A reminder to hepatologists and gastroenterologists about autoimmune hepatitis

TYPE OF AUTOANTIBODIES

VALUE(S)

Anti-nuclear

Autoimmune hepatitis type 1. In low titers, they do not have specificity And can affect the functions of the nucleus

Anti-smooth muscle

Autoimmune hepatitis type 1.  Viral infections are characterized by antibodies to the non-actin component

Antiactinic

They are highly specific for autoimmune hepatitis type 1. They can facilitate surface binding of antibodies

Anti-LKM-l

Autoimmune hepatitis type 2. They inhibit P450 IID6 in vitro. They are often found in viral hepatitis C

Type 1 anti-cytosolic (to the cytosol of hepatocytes)

Related to anti-LKM-1. They are not often found in viral hepatitis C. They are detected in young patients with a severe course of the disease (unlike anti-LKM-1, which are usually associated with a milder course of the disease).

To a soluble liver antigen

Autoimmune hepatitis type 3. Markers of cryptogenic chronic hepatitis. They can be detected in autoimmune hepatitis type 1.

To the liver/pancreas

Autoimmune hepatitis type 3. Markers of cryptogenic chronic hepatitis. They can be detected in autoimmune hepatitis type 1.

To asialoglycoprotein receptors

Autoimmune markers. They may reflect the activity of the inflammatory process.

Perinuclear antineutrophil cytoplasmic antibodies

They are present in most patients. High credits. Belong to the lgG1 isotype, the function is unknown.