Anti-Rub IgG (IgG class antibodies to rubella virus)

Rubella is an acute infectious disease transmitted by respiratory droplets; the causative agent is the rubella virus of the Rubivirus genus. 

It is included in the group of TORCH-infections, i.e. the group of diseases of pregnant women that pose a special danger to the intrauterine development of the fetus.

On average, 33% of women have a potential risk of infection during pregnancy. The main clinical manifestation is the appearance of finely-spotted rash on the body and lymph nodes enlargement. In 40% of cases, rubella is asymptomatic, but the greatest danger to the fetus is the latent form of rubella, accompanied by the prolonged presence of the virus in the body of the pregnant woman.

If a woman is infected in the first two months of pregnancy, the fetus has a very high risk of developing heart defects and damage to the visual organs. Infection in the third or fourth month is a risk of severe malformations of the central nervous system and hearing organs. If a woman gets sick in the first 6 weeks of pregnancy, the risk of congenital anomaly is 56%, at 13-16 weeks - from 6 to 10 percent. After 16 weeks - no particular risk is noted. An accurate diagnosis of rubella can only be made by detecting specific IgG and IgM antibodies to the rubella virus.

Anti-Rub IgG are antibodies to the rubella virus that appear a few days after the body has come into contact with the infectious agent, which can be not only during infection but also during vaccination. Anti-Rub IgG are detected 3 days after the appearance of the specific rash in 50% of patients. On day 8 - in 90%. On day 20 - in almost all surveyed. The absence of antibodies in a newborn excludes congenital infection. The main purpose of prescribing the test is to diagnose the patient's immune defense against rubella virus. An increase in the number of antibodies in the dynamics with an interval of 2 weeks is a sign of the presence of the disease, not immunity. Below are graphs of the dynamics of the main markers of congenital and acquired rubella.