Free (reduced) glutathione (chromatography)
Reduced (Free) Glutathione is a key biomarker of the body's antioxidant defense system.
Reduced glutathione is the primary intracellular antioxidant that protects cells against oxidative stress by neutralizing reactive oxygen species (ROS) and other reactive molecules. It plays a crucial role in maintaining cellular health, preventing damage to DNA, proteins, and lipids, and supporting the body's detoxification processes.
A decreased level of reduced glutathione reflects impaired antioxidant defense and may be associated with an increased risk of chronic diseases, inflammatory conditions, and accelerated cellular aging.
Glutathione is widely regarded as the body's universal "antioxidant shield" against oxidative damage. Its protective role is particularly important in cardiovascular diseases, diabetes, chronic inflammatory disorders, neurodegenerative diseases, and cancer.
Measuring the level of reduced glutathione provides valuable information about the functional status of the antioxidant system and helps clinicians optimize therapeutic strategies.
The Reduced Glutathione test is performed using High-Performance Liquid Chromatography (HPLC), ensuring accurate and reliable measurement of the active form of glutathione in blood.
This assay is widely used for diagnosis, treatment monitoring, and evaluating the effectiveness of preventive interventions aimed at reducing oxidative stress.
When is the test recommended?
- To assess the body's antioxidant defense status.
- In patients with chronic inflammatory and metabolic diseases.
- For monitoring patients with cancer.
- To evaluate the effectiveness of treatment and preventive measures aimed at reducing oxidative damage to cells.
Why is this important ?
The body's antioxidant defense system is one of the key mechanisms for maintaining the health of cells and tissues.
A reduced level of reduced glutathione may indicate increased susceptibility to oxidative stress, accelerated cellular aging, and a higher risk of developing chronic diseases.
Measuring glutathione levels helps physicians gain a comprehensive understanding of a patient's biochemical status and optimize treatment and preventive strategies.