Glucose Tolerance Test with Insulin and C-peptide
The glucose tolerance test with insulin and C-peptide detection is an advanced laboratory examination that allows not only to assess glucose levels, but also to analyze in detail the response of the pancreas to carbohydrate load.
The examination makes it possible to identify insulin resistance, hyperinsulinemia, early carbohydrate metabolism disorders, and to assess the functional state of β-cells.
The test makes it possible to identify insulin resistance, hyperinsulinemia,
early carbohydrate metabolism disorders, and assess the functional state of the pancreatic β-cells.
Why is the analysis performed ?
The test is prescribed to:
- detect insulin resistance in the early stages, even with normal glucose levels;
- perform differential diagnosis of hyperinsulinemia and reactive hypoglycemia;
- assess insulin and peptid secretion (β-cell function);
- detection of the causes of carbohydrate metabolism disorders;
- control of the effectiveness of therapy in patients with: obesity, metabolic syndrome, polycystic ovary syndrome (PCOS), type 2 diabetes mellitus; monitoring for suspected decreased insulin secretion and β-cell depletion.
How the test is performed
- Sampling of blood on an empty stomach (8-12 hours of fasting): glucose, insulin, C-peptide.
- Solution intake: 75 g of glucose dissolved in 250-300 ml of water, to be drunk within 5 minutes.
- Repeat blood sampling 2 hours after the load (glucose, insulin, C-peptide).