Organic acids in urine - detection of functional metabolic changes (60 indicators): markers of carbohydrate metabolism; markers of metabolism in the tricarboxylic acid cycle (in the Krebs cycle), cellular energy supply, mitochondrial dysfunction, markers of ketogenesis, dysregulation of carbohydrate metabolism and beta-oxidation of fatty acids; markers of metabolism of branched amino acids; markers of aromatic amino acid (phenylalanine and tyrosine) metabolism; markers of tryptophan metabolism; markers of oxalic acid (oxalates) metabolism; markers of vitamin sufficiency; markers of cofactor methylation; markers of detoxification and endogenous intoxication; markers of benzene derivatives intoxication; markers of intestinal dysbiosis.
"Organic acids in urine - identification of functional metabolic changes (60 indicators): carbohydrate metabolism markers; tricarboxylic acid cycle metabolism markers (Krebs cycle), energy supply to cells, mitochondrial dysfunction, ketogenesis markers, dysregulation of carbohydrate metabolism and beta-oxidation of fatty acids; branched-chain amino acid metabolism markers; aromatic amino acids metabolism markers (phenylalanine and tyrosine); tryptophan metabolism markers; oxalic acid (oxalate) metabolism markers; vitamin adequacy markers; cofactor methylation markers; detoxification and endogenous intoxication markers; benzol derivatives intestinal intoxication markers. Parameters determined in the laboratory
Carbohydrate metabolism markers
Lactic acid (lactate, E270)
Pyruvic acid (pyruvate)
Metabolism markers in the tricarboxylic acid cycle (Krebs cycle), energy supply to cells, mitochondrial dysfunction, amino acid metabolism, sufficiency of B vitamins, coenzyme Q and Mg
Citric acid (citrate, E330)
cis-Aconitic acid (propylene tricarboxylic)
Isocitric acid (isocitrate)
2-Ketoglutaric Acid (2-Oxoglutaric Acid)
Succinic acid (succinic acid, succinate, E363)
Fumaric acid (boletic acid, E297)
Malic acid (malate, hydroxy succinic acid, E296)
2-Methylglutaric (2-methylpentanedioic acid)
Byproduct metabolite of succinic acid.
Markers of ketogenesis, dysregulation of carbohydrate metabolism and beta-oxidation of fatty acids
Acetoacetic acid (3-ketobutyric acid, acetoacetate)
3-Hydroxybutyric acid
Malonic acid (propanedioic acid)
Branched Chain Amino Acid Metabolism Markers
Valine, Leucine, Isoleucine
2-Hydroxy-3-methylbutanoic acid (2-hydroxyisovaleric acid)
Incl. indirect mitochondrial dysfunction marker.
3-Methylcrotonylglycine
Incl. even carbon fatty acid metabolite
Leucine
3-Methylglutaric acid (3-methylpentanedioic acid)
Incl. indirect mitochondrial dysfunction marker.
Isovalerylglycine (N-isopentanoylglycine)
Aromatic amino acid metabolism markers (phenylalanine and tyrosine)
para-hydroxyphenyl lactic acid
Incl. antioxidant and vitamin C deficiency marker.
para-Hydroxyphenylpyruvic acid
Incl. bacterial intestinal dysbiosis marker.
Homogentisic acid (2,5-dihydroxyphenylacetic acid, melanic acid)
Incl. bacterial intestinal dysbiosis marker.
3-Phenyl-lactic acid (2-hydroxy-3-phenylpropionic acid)
Phenylglyoxylic acid (benzoyl formic)
Including styrene metabolite (refer "Detoxification and endogenous intoxication markers").
Mandelic acid (phenyl glycolic acid)
Including styrene metabolite (refer "Detoxification and endogenous intoxication markers").
Tryptophan Metabolic Markers
Quinolinic acid (quinolinic; 2,3-pyridinedicarboxylic acid)
Incl. infectious inflammation marker.
Picolinic acid
Incl. T-cell immunity activation marker.
Oxalic acid (oxalate) metabolism markers)
Glycolic acid (hydroxyacetic acid)
Glyceric acid (2,3-dihydroxypropanoic acid)
Oxalic acid (ethanedioic, oxalic acid)
Vitamin Adequacy Markers
B2, B5 vitamin, microsomal omega-fatty acid oxidation and carnitine deficiency adequacy markers
2- Ketoisovaleric acid
Incl. valine metabolite.
3- Methyl 2-oxovalerianic acid (3-methyl-2-oxopentanoic acid)
Incl. isoleucine metabolite.
4-Methyl-2-oxovaleric acid (2-ketoisocaproic acid)
Incl. leucine metabolite.
Vitamin B2 adequacy markers
Glutaric acid (pentanedioic acid)
Sebacic acid (decanedioic acid)
Adipic acid (hexanedioic acid, E355)
Suberic acid (cork, octanedioic acid)
B2, B5 vitamins and auxiliary oxidation of butyrate adequacy markers (butyric acid)
Ethylmalonic acid (2-carboxybutyric acid)