Tropomyosin, House dust mite rDer p 10 IgE, d205
Der p 10 is one of the secondary allergens of house dust mites (HDM), the prevalence of which among sensitized Dermatophagoides pteronyssinus patients ranges from 5 to 18%.
Allergocomponent diagnostics is based on the detection of sensitization to allergens at the molecular level using natural highly purified and recombinant allergen molecules, that is, their individual allergen components.
There are 3 main analysis of doing this analysis:
- Allergocomponent diagnostics, makes it possible to differentiate true sensitization from sensitization due to cross-reactivity. This data will help determine the sources of allergies: one single allergy, several closely related ones, or many different ones.
- Molecular allergy diagnostics will eliminate the need for provocative tests and allow you to give clearer recommendations regarding the elimination of contact with allergens.
- Molecular allergodiagnostics is necessary in the selection of ASIT, in persons with polyvalent (multiple) sensitization, the most accurate way to determine the most important allergen for which therapy will be performed.
The allergenic substance contains not one but several protein components that can act as allergens:
- Major allergen components are the main allergenic molecules, antibodies to which are found in more than half – 50% of patients in the population responding to this source. They are resistant to heat and more immunogenic. They are large and are contained in this allergen in larger quantities.
- Minor are secondary smaller in size and less immunogenic allergenic molecules that are usually contained in smaller amounts in the allergen but are present in many different allergens, sometimes not closely related, providing cross-allergy. That is, allergens with a prevalence of more than 50% are called major allergens and less than 10% are called minor allergens.
The most important house dust mites are Dermatophagoides pteronyssinus, they can be found in mattresses, carpets, blankets, pillows, etc. As a rule, they feed on dead skin epithelium, which a person loses daily.
Specific immunoglobulin E (sIgE) to Der p 10 is associated with respiratory symptoms including rhinitis, conjunctivitis, cough and shortness of breath.
There is a high degree of cross-reactivity between Der p 10, Der f 10 and Blo t 10 and Lep d 10. Der p 10 is a tropomyosin and can cause a cross-reaction with tropomyosin of crustaceans (shrimp, crabs, lobsters, snails, crayfish), shellfish (mussels, oysters, scallops, snails, abalone, squid, cuttlefish, octopus).
Der p 10 can be a diagnostic biomarker for patients with tick allergy with additional sensitization to allergens other than Der p 1 and Der p 2. Therefore, when conducting immunotherapy with allergen extracts, special attention should be paid to these patients."