Нәжістегі зонулин
Fecal zonulin is a laboratory test used to assess the integrity of the intestinal barrier (intestinal permeability). Zonulin is a protein that regulates the function of tight junctions between the cells of the intestinal mucosa. Elevated zonulin levels may impair the intestinal barrier, allowing bacterial components, toxins, and undigested food particles to pass into the body.
Increased intestinal permeability is considered one of the mechanisms involved in the development of various gastrointestinal diseases, as well as allergic, autoimmune, and metabolic disorders. In children, impaired intestinal barrier function may also be associated with the development of the atopic march.
The test is recommended as part of a comprehensive diagnostic evaluation in patients with chronic gastrointestinal symptoms (bloating, abdominal pain, altered bowel habits), suspected increased intestinal permeability ("leaky gut syndrome"), inflammatory bowel diseases, celiac disease, food intolerance, and for monitoring the effectiveness of treatment and follow-up over time.