Phosphorus
Inorganic phosphorus in urine is a trace element that performs a number of vital functions in the body: Synthesis of an energy substrate (ATP, ADP) necessary for the vital activity of any cell; Formation of bone tissue; Maintenance of calcium–phosphorus balance in the blood. 85% of the total amount of phosphorus is located in the bone structure, 14% inside the cells, the remaining 1 percent is in the extracellular fluid. The parathyroid gland is responsible for phosphorus metabolism, which reduces its concentration by excretion through the kidneys. The phosphorus content is directly related to calcium, an increase in which leads to the excretion of phosphorus in the urine. The main purpose of the test is to determine the cause of a violation of calcium metabolism. Below is a table showing the level of calcium and phosphorus in the blood and urine in various pathological conditions:
DISEASE | CAUSE | CA PARATHYROID HORMONE | Blood | Urine | Blood | Urine |
---|---|---|---|---|---|---|
Primary hyperparathyroidism | Parathyroid adenoma, parathyroid hyperplasia, parathyroid cancer | ↑ | ↑ | ↓ | ↑ norm | ↑↑ |
Secondary hyperparathyroidism | CRF | ↓↓ | ↓ | ↑ | ↓ | ↑ |
Malabsorption | Metabolic disorder vit. D3 | Deficiency of minerals in food | ↓↓ | ↓ | ↓ | norm |
Hypoparathyroidism | Removal of n/a | Idiopathic Di Giorgi Syndrome | ↓ | ↓ | ↑ | ↓ |
Hypopsevdo-parathyroidism | Defect of PTH receptors | ↓ | ↓ | ↑ | ↓ | ↑ |
Osteomalacia | Rickets | Deficiency of vit. D | ↓ | ↑ | ↓ | ↑ |
Increased PTH binding protein for lung, kidney, esophageal, breast, and bladder cancers | ↑ | ↑ | ↓ | ↑ norm | Breast cancer; Prostate; Multiple myeloma, etc. | ↑ |
Hyperthyroidism | Adenoma; Goiter; Carcinoma, etc. | ↑ | ↑ | norm | ↑ | norm |
Norm | Milk-alkali syndrome | ↑ | ↑ | norm | ↑ | norm |
Hypervitaminosis D is | Incorrect dosage; Self-treatment | ↑ | ↑ | ↑ | norm | ↑ |
Acute pancreatitis | Formation of calcium soaps | ↓ | ↓ norm | ↓ | norm | |
Thiazide diuretics | Decrease in calcium excretion | ↑ | ↑ | norm | norm | norm |