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Phosphorus

Inorganic phosphorus in urine is a trace element that performs a number of vital functions in the body: Synthesis of an energy substrate (ATP, ADP) necessary for the vital activity of any cell; Formation of bone tissue; Maintenance of calcium–phosphorus balance in the blood. 85% of the total amount of phosphorus is located in the bone structure, 14% inside the cells, the remaining 1 percent is in the extracellular fluid. The parathyroid gland is responsible for phosphorus metabolism, which reduces its concentration by excretion through the kidneys. The phosphorus content is directly related to calcium, an increase in which leads to the excretion of phosphorus in the urine. The main purpose of the test is to determine the cause of a violation of calcium metabolism. Below is a table showing the level of calcium and phosphorus in the blood and urine in various pathological conditions:

DISEASE CAUSE CA PARATHYROID HORMONE Blood Urine Blood Urine
Primary hyperparathyroidism Parathyroid adenoma, parathyroid hyperplasia, parathyroid cancer ↑ norm ↑↑
Secondary hyperparathyroidism CRF ↓↓
Malabsorption Metabolic disorder vit. D3 Deficiency of minerals in food ↓↓ norm
Hypoparathyroidism Removal of n/a Idiopathic Di Giorgi Syndrome
Hypopsevdo-parathyroidism Defect of PTH receptors
Osteomalacia Rickets Deficiency of vit. D
Increased PTH binding protein for lung, kidney, esophageal, breast, and bladder cancers ↑ norm Breast cancer; Prostate; Multiple myeloma, etc.
Hyperthyroidism Adenoma; Goiter; Carcinoma, etc. norm norm
Norm Milk-alkali syndrome norm norm
Hypervitaminosis D is Incorrect dosage; Self-treatment norm
Acute pancreatitis Formation of calcium soaps   ↓ norm norm
Thiazide diuretics Decrease in calcium excretion norm norm norm