Determination of Ig G for the capsid antigen of the Epstein-Barr virus (HSV-IV) in the serum by the ELISA method

Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis. According to several scientific analysis contribute to the development of numerous other pathologies, including lymphoma, chronic fatigue syndrome and multiple sclerosis.

Antibodies of the class (immunoglobulins) IgG is a specific component of the body's immune system that aims to destroy a certain foreign protein. In the case of a diagnosis of HEB, the protein that provokes immunity to IgG production is the envelope-capsid of the virus. IgG appear during the height of the disease, reaching its peak by the second month. Upon recovery, the antibody titer decreases and may persist in the body for several years. Thus, the detection of IgG in the blood means either the transition of the disease into a chronic form, or a strong immunity against the pathogen. To distinguish these two states, it is necessary to perform dynamic test and observe the decrease, increase or absence of changes in the results.

For optimal diagnosis, two tests should be administered at the same time: IgM and IgG antibodies to the capsid antigen of Epstein-Barr virus.

The test allows differentiation between acute and chronic disease: in the acute period of the disease, an increase in IgM levels will be accompanied by normal or slightly elevated IgG. In chronic course - vice versa: against the background of high concentration of IgG, the level of IgM will be insignificant.

In case of a negative test result in the presence of a clinical picture, the analysis should be repeated in 2-4 weeks.

Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis. According to several scientific analysis contribute to the development of numerous other pathologies, including lymphoma, chronic fatigue syndrome and multiple sclerosis. Antibodies of the class (immunoglobulins) IgG is a specific component of the body's immune system that aims to destroy a certain foreign protein. In the case of a diagnosis of HEB, the protein that provokes immunity to IgG production is the envelope-capsid of the virus. IgG appear during the height of the disease, reaching its peak by the second month. Upon recovery, the antibody titer decreases and may persist in the body for several years. Thus, the detection of IgG in the blood means either the transition of the disease into a chronic form, or a strong immunity against the pathogen. To distinguish these two states, it is necessary to perform dynamic test and observe the decrease, increase or absence of changes in the results.

 For optimal diagnosis, two tests should be administered at the same time: IgM and IgG antibodies to the capsid antigen of Epstein-Barr virus. The test allows differentiation between acute and chronic disease: in the acute period of the disease, an increase in IgM levels will be accompanied by normal or slightly elevated IgG. In chronic course - vice versa: against the background of high concentration of IgG, the level of IgM will be insignificant. In case of a negative test result in the presence of a clinical picture, the analysis should be repeated in 2-4 weeks.