Apple, f49

The apple is one of the most popular fruits grown and consumed worldwide. It belongs to the Rosaceae family and the apple tree genus.
The fruits of the Rosaceae family are known pathogens of food allergies. Symptoms of an apple allergy occur when apples are consumed directly or through indirect contact with fruits, for example, when eating foods containing apples. Apple allergy is mainly manifested by oral allergy syndrome (OAS) with swelling and itching of the mucous membrane of the mouth, throat, lips, itchy eyes, etc., allergic rhinitis and asthma in others, and even severe systemic symptoms such as anaphylaxis in some people.

There are four main allergens of apples: Mal d 1, Mal d 2, Mal d 3 and Mal d 4. Apple allergy demonstrates a close relationship with birch pollen allergy, as Mal d 1 demonstrates a high level of cross-reactivity with the main allergen of birch pollen Bet v 1. Mal d 2 exhibits cross-reactivity with another allergen of birch pollen Bet v 2. Significant cross-reactivity is observed between apples and other members of the rose-flower family, as well as with allergens of kiwi, grapes, birch pollen, and pollen of the grass group. In addition, it has been found that ripe apples cause more allergies than freshly picked apples.

Sensitive people are advised to avoid highly allergenic varieties of apples and observe basic hygiene around themselves to prevent the appearance of symptoms of allergy to apples. 

The determination of specific IgE in human blood to - Apple, f49, shows the body's reaction to this allergen.

Research method: ImmunoCAP method (Immunofluorescence in the solid phase)

Units of measurement: kU/l

Biomaterial for analysis: venous blood